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内容编辑TLR4敲除小鼠
分类: 免疫炎症鼠
发布时间: 2019-08-09 11:00
应用：炎症反应
级别：SPF
类型：KO
背景：C57BL/6
名称：TLR4-KO
编号：LM000204
级别：SPF
类型：KO
背景：C57BL/6
名称：TLR4-KO
编号：LM000204
使用基因编缉技术删除TLR4基因外显子，建立TLR4基因敲除小鼠模型。可用于先天免疫反应和炎症的相关研究。Toll样受体4（Toll-like receptors 4, TLR4）是参与非特异性免疫（天然免疫）的一类重要蛋白质分子，也是连接非特异性免疫和特异性免疫的桥梁。Toll样受体信号转导导致多种细胞反应，包括产生干扰素（IFNs）、促炎细胞因子和调控适应性免疫反应的效应细胞因子。Toll样受体通路在各种自身免疫性疾病中起重要的调节作用。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |