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内容编辑IL-10敲除小鼠
分类: 免疫炎症鼠
发布时间: 2019-08-12 11:00
应用：结肠炎
级别：SPF
类型：KO
背景：C57BL/6
名称：IL-10-KO
编号：LM000201
级别：SPF
类型：KO
背景：C57BL/6
名称：IL-10-KO
编号：LM000201
使用基因编缉技术将小鼠IL-10删除，获得IL-10敲除小鼠。IL-10是由免疫细胞和非免疫细胞分泌的重要的抗炎细胞因子，作用于先天性和适应性免疫细胞，并具有广泛的免疫调节活性。可抑制增殖、细胞因子分泌与共刺激分子表达。溃疡性结肠炎（UC）是肠粘膜局部免疫反应的异常造成，结肠炎的发展涉及TLR诱导的NF-κB活化，主要来源于粘膜免疫细胞。IL-10的缺失导至肠道免疫细胞不能发挥其炎性抑制作用，是IL-10敲除小鼠炎症发展的关键。
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