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内容编辑Zap70-W163C小鼠
分类: 免疫炎症鼠
发布时间: 2019-08-13 11:00
应用：类风湿性关节炎、强直性脊柱炎、SKG
级别：SPF
类型：PM
背景：Balb/c
名称：Zap70-W163C
编号：LM000200
级别：SPF
类型：PM
背景：Balb/c
名称：Zap70-W163C
编号：LM000200
W163C SKG
使用基因编缉技术将小鼠Zap70蛋白的163位氨基酸由W替换为C，伴有关节肿胀，表现出风湿性关节炎（rheumatoid arthritis, RA）、强直性脊柱炎（ankylosing spondylitis，AS）等症状，还伴有间质性肺炎、皮炎、血管炎和类风湿结节样病变。SKG模型。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |
使用基因编缉技术将小鼠Zap70蛋白的163位氨基酸由W替换为C，伴有关节肿胀，表现出风湿性关节炎（rheumatoid arthritis, RA）、强直性脊柱炎（ankylosing spondylitis，AS）等症状，还伴有间质性肺炎、皮炎、血管炎和类风湿结节样病变。SKG模型。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |