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Tp53条件性敲除小鼠
分类: 自发肿瘤鼠
发布时间: 2019-08-18 11:00
应用:肿瘤
级别:SPF
类型:CKO
背景:C57BL/6
名称:Tp53-flox
编号:LM000195
级别:SPF
类型:CKO
背景:C57BL/6
名称:Tp53-flox
编号:LM000195
Trp53
使用基因编缉技术在Trp53基因exons两侧分别插入loxP位点,与组织特异性Cre鼠交配可获得在特定细胞类型或组织中Trp53基因敲除小鼠模型。由于抑癌基因Trp53缺失,细胞失去了对细胞生长、凋亡和DNA 修复的调控,容易诱发细胞引起癌变。该小鼠可用以研究各类肿瘤的发生、发展,及肿瘤相关药物的筛选。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |
使用基因编缉技术在Trp53基因exons两侧分别插入loxP位点,与组织特异性Cre鼠交配可获得在特定细胞类型或组织中Trp53基因敲除小鼠模型。由于抑癌基因Trp53缺失,细胞失去了对细胞生长、凋亡和DNA 修复的调控,容易诱发细胞引起癌变。该小鼠可用以研究各类肿瘤的发生、发展,及肿瘤相关药物的筛选。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |
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