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内容编辑Dlgap2敲除小鼠
分类: 神经退行性疾病鼠
发布时间: 2019-08-29 11:00
应用：阿尔茨海默症、AD
级别：SPF
类型：KO
背景：C57BL/6
名称：Dlgap2-KO
编号：LM000184
级别：SPF
类型：KO
背景：C57BL/6
名称：Dlgap2-KO
编号：LM000184
使用基因编缉技术删除Dlgap2基因外显子，建立Dlgap2敲除小鼠模型。Dlgap2基因的表达与小鼠记忆缺失的程度和人类阿尔兹海默氏痴呆症风险有关，Dlgap2能够影响神经元上树突棘（dendritic spines）的形成，其会影响大脑的认知功能，在小鼠机体中，长而细的诸如蘑菇样的棘状结构要比较粗的棘状结构展现出更高的精神表现，而认知能力的下降则与树突棘的缺失直接相关。老年痴呆症小鼠模型，阿尔茨海默症小鼠模型，AD小鼠模型。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |