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SHR大鼠
分类: 心血管疾病鼠
发布时间: 2019-09-13 11:00
应用:自发性高血压
级别:SPF
类型:近交系
毛色:白化
名称:SHR
编号:LM000169
级别:SPF
类型:近交系
毛色:白化
名称:SHR
编号:LM000169
自发性高血压大鼠(Spontaneous Hypertension Rat,SHR)是原发性自发形成高血压的大鼠。在1961年左右,日本京都大学(Kyoto University)医学院Okamoto(Kozo Okamoto)实验室在Wistar大鼠中将具有自发性高血压(尾静脉压即收缩压150-175mmHg)的雄性Wistar大鼠(7周龄)与血压稍高于平均水平的(收缩压140-150mmHg)雌性Wistar大鼠交配,从所得的F1代开始进行近交筛选。在近交筛选过程中观察到,随着代数增加,自发性高血压发生率逐渐增大,而发生的时间(年龄)越来越早,严重高血压(高于200mmHg)的大鼠发生率也越来越高。最终形成了所有雄性和雌性自发高血压发生率100%的近交系SHR。
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