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OT-1小鼠
分类: 免疫肿瘤鼠
发布时间: 2019-10-15 11:00
应用：T细胞
级别：SPF
类型：TG
背景：C57BL/6
名称：OT-1
编号：LM000137
TcraTcrb
使用基因编缉技术使小鼠有Tcra-V2与Tcrb-V5基因的插入突变，OT-1小鼠的CD8+ T细胞受体特异性识别OVA 257-264肽段。OT-1小鼠可用于研究多肽在CD8+T细胞对抗原的阳性选择和应答中的作用。和大多数转基因TCR一样，这些小鼠有一定的免疫缺陷。
| 疾病造模 | 代养代繁 | 药效评估 | 生化分析 | 行为分析 | 影像检测 | 病理检测 |
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